AICAR is a metabolic compound that activates AMP-activated protein kinase (AMPK), often referred to as the body's "energy sensor." By stimulating AMPK, AICAR promotes glucose uptake, fatty acid oxidation, mitochondrial activity, and improved metabolic efficiency. It has been extensively studied for endurance enhancement, fat loss, insulin sensitivity, and metabolic health.
Common Research Dosing Protocol:
250-500 mg daily
Common starting dose: 250 mg daily
Advanced protocols: 500 mg daily
Typical cycle length: 4-8 weeks
Administration:
Subcutaneous injection
Often administered 30-60 minutes before exercise
Can also be taken at a consistent time each day for metabolic support
Storage:
Refrigerate at 36-46°F (2-8°C) after reconstitution
Protect from light
Do not freeze
Use sterile technique for all withdrawals
Notes:
AICAR is often researched as an "exercise mimetic" because it can activate some of the same metabolic pathways stimulated by endurance training. Users commonly report increased workout endurance, improved recovery between sets, enhanced fat utilization, and better insulin sensitivity. It is sometimes stacked with compounds such as MOTS-C, SS-31, or GLP-1 receptor agonists in metabolic optimization protocols. Because AICAR can significantly affect glucose metabolism, individuals monitoring blood glucose should pay close attention to changes in blood sugar levels during use.
AICAR is a metabolic compound that activates AMP-activated protein kinase (AMPK), often referred to as the body's "energy sensor." By stimulating AMPK, AICAR promotes glucose uptake, fatty acid oxidation, mitochondrial activity, and improved metabolic efficiency. It has been extensively studied for endurance enhancement, fat loss, insulin sensitivity, and metabolic health.
Common Research Dosing Protocol:
250-500 mg daily
Common starting dose: 250 mg daily
Advanced protocols: 500 mg daily
Typical cycle length: 4-8 weeks
Administration:
Subcutaneous injection
Often administered 30-60 minutes before exercise
Can also be taken at a consistent time each day for metabolic support
Storage:
Refrigerate at 36-46°F (2-8°C) after reconstitution
Protect from light
Do not freeze
Use sterile technique for all withdrawals
Notes:
AICAR is often researched as an "exercise mimetic" because it can activate some of the same metabolic pathways stimulated by endurance training. Users commonly report increased workout endurance, improved recovery between sets, enhanced fat utilization, and better insulin sensitivity. It is sometimes stacked with compounds such as MOTS-C, SS-31, or GLP-1 receptor agonists in metabolic optimization protocols. Because AICAR can significantly affect glucose metabolism, individuals monitoring blood glucose should pay close attention to changes in blood sugar levels during use.